Aspergillus Peptide Mix 1&2 Elispot

Aspergillus Peptide Mix 1&2 EliSpot
AONM/ArminLabs

"AONM have checklists that help identify the most likely viral or bacterial infections to test for, based on patient symptoms. Please see https://aonm.org/checklists-for-testing/ or contact AONM at 03331 210305 or email info@aonm.org. We also offer different viral and bacterial panels, and are always happy to advise on testing options."

Please note this test requires a blood draw, please organise a phlebotomist for your patient. A return courier fee of £50 is included in this test price

Description:
This test reflects the current activity of Aspergillus species in chronic and recent infections. The EliSpot is highly sensitive and can detect even one single Aspergillus-reactive T-cell. With detection levels that can be as low as one cell in 100,000, the EliSpot is one of the most sensitive cellular assays available.

Methodology:
Aspergillus Peptide Mix 1&2 EliSpot T-Cell-Spot / IGRA: Interferon-Gamma-Release Assay)

When should I use:
When a recent or chronic case of Aspergillus infection is suspected, particularly in individuals with respiratory symptoms or compromised immune systems.

Other details:
AONM has checklists that help identify the most likely fungal or bacterial infections to test for, based on patient symptoms. Please see https://aonm.org/checklists-for-testing/ or contact AONM at 03331 210305 or email info@aonm.org. We also offer different fungal and bacterial panels and are always happy to advise on testing options. The EliSpot can be helpful when monitoring therapies.

The EliSpot should usually become negative about 4 to 8 weeks after the completion of an effective therapy.

Aspergillus Species:

• Description: Aspergillus is a genus of moulds found in the environment. Infections caused by Aspergillus, known as aspergillosis, can range from mild to severe and typically affect the respiratory system.
• Symptoms:

• Allergic Bronchopulmonary Aspergillosis (ABPA): Wheezing, coughing, shortness of breath, and fever in individuals with asthma or cystic fibrosis.
• Chronic Pulmonary Aspergillosis: Cough, haemoptysis (coughing up blood), weight loss, fatigue, and breathing difficulties.
• Invasive Aspergillosis: Fever, chest pain, cough, and shortness of breath, predominantly in immunocompromised patients.
• Aspergilloma (Fungal Ball): Coughing, sometimes with blood, and other respiratory symptoms, typically in individuals with pre-existing lung cavities.

Significance of Testing for Aspergillus:

• Differentiation: By testing for Aspergillus-specific antigens (Peptide Mix 1&2), the EliSpot can help confirm the presence of the fungus and differentiate between colonisation and active infection.

Biomarkers

Aspergillus Peptide Mix 1&2 EliSpot

Specification

Specimen Type:

3 x CPDA tube

Vitality of T-cells for LTT: Up to 3 days

Phlebotomy Type:

Blood draw at home or in a clinical setting