Coeliac Profile

The Genova Diagnostics Celiac Profile is designed to help diagnose celiac disease and assess the body's immune response to gluten. Celiac disease is an autoimmune disorder where ingestion of gluten leads to damage in the small intestine. This comprehensive profile evaluates various markers to provide a thorough assessment.

Key Components of the Genova Celiac Profile Test

1. Anti-tTG (Tissue Transglutaminase Antibodies):

   • IgA and IgG: Measures the immune response to tissue transglutaminase, an enzyme involved in the small intestine's repair and maintenance. Elevated levels are commonly seen in celiac disease.

2. Anti-DGP (Deamidated Gliadin Peptide Antibodies):

   • IgA and IgG: Detects antibodies against deamidated gliadin peptides, which are more specific to celiac disease compared to native gliadin antibodies.

3. Total Serum IgA:

   • Assesses the overall level of IgA to ensure that a deficiency is not present, which could affect the accuracy of other IgA-based tests.

4. Anti-Gliadin Antibodies:

   • IgA and IgG: Measures antibodies against gliadin, a component of gluten. While less specific than anti-DGP, elevated levels can still indicate gluten sensitivity or celiac disease.

5. HLA-DQ2/DQ8 Genotyping:

   • Identifies genetic markers associated with celiac disease. Most individuals with celiac disease have one or both of these genetic markers.

Benefits of the Celiac Profile Test

1. Comprehensive Evaluation: Provides a detailed assessment of various immune responses to gluten, increasing the accuracy of celiac disease diagnosis.
2. Identification of Gluten Sensitivity: Helps differentiate between celiac disease, non-celiac gluten sensitivity, and other gluten-related disorders.
3. Guiding Dietary Changes: Assists healthcare providers in recommending dietary adjustments, such as a gluten-free diet, based on test results.
4. Monitoring Disease Progression: Useful for tracking the effectiveness of a gluten-free diet and monitoring the autoimmune response over time.
5. Genetic Risk Assessment: The inclusion of HLA-DQ2/DQ8 genotyping helps identify genetic predisposition to celiac disease, which is useful for family members of individuals with confirmed celiac disease.