HHV-7 Elispot

HHV-7 EliSpot

AONM/ArminLabs

HSV 1 + 2 EliSpot
AONM/ArminLabs

"AONM have checklists that help identify the most likely viral or bacterial infections to test for, based on patient symptoms. Please see https://aonm.org/checklists-for-testing/ or contact AONM at 03331 210305 or email info@aonm.org. We also offer different viral and bacterial panels, and are always happy to advise on testing options."

Please note this test requires a blood draw, please organise a phlebotomist for your patient. A return courier fee of £50 is included in this test price

Description:
This test reflects the current activity of Herpes Simplex Virus type 1 (HSV-1) and type 2 (HSV-2) in chronic and recent infections.

Herpes Simplex Virus (human herpesvirus HHV1/2) (always intercellular), double-stranded DNA virus, one of the herpes viruses.

The EliSpot is highly sensitive and can detect even one single HSV-1 or HSV-2-reactive T-cell. With detection levels that can be as low as one cell in 100,000, the EliSpot is one of the most sensitive cellular assays available.

Methodology:
HSV 1 + 2 EliSpot (T-Cell-Spot / IGRA: Interferon-Gamma-Release Assay)

When should I use:
When a recent or chronic case of HSV-1 or HSV-2 infection is suspected.

Other details:
AONM has checklists that help identify the most likely viral or bacterial infections to test for, based on patient symptoms. Please see https://aonm.org/checklists-for-testing/ or contact AONM at 03331 210305 or email info@aonm.org. We also offer different viral and bacterial panels and are always happy to advise on testing options. The EliSpot can be helpful when monitoring therapies.

The EliSpot should usually become negative about 4 to 8 weeks after completion of an effective therapy.

Herpes Simplex Virus 1 (HSV-1):

• Description: HSV-1 is primarily associated with oral herpes but can also cause genital herpes. It typically results in cold sores or fever blisters around the mouth.
• Symptoms:
• Cold Sores: Painful blisters on the lips or around the mouth.
• Fever: Low-grade fever may accompany the sores.
• Sore Throat: Irritation or pain in the throat.
• Swollen Lymph Nodes: Particularly in the neck area.
• Fatigue: Generalised tiredness and weakness.

Herpes Simplex Virus 2 (HSV-2):

• Description: HSV-2 is primarily associated with genital herpes but can also cause oral herpes. It typically results in sores or blisters in the genital area.
• Symptoms:
• Genital Sores: Painful blisters or ulcers in the genital or anal area.
• Painful Urination: Burning sensation during urination.
• Itching or Irritation: In the genital area.
• Swollen Lymph Nodes: Particularly in the groin area.
• Fever and Flu-like Symptoms: Including headache, muscle aches, and fatigue.

Significance of Testing Both HSV-1 and HSV-2:

• Differentiation: By testing for both HSV-1 and HSV-2, the EliSpot can help differentiate between infections caused by either type, which is important for appropriate treatment and management.
• Monitoring: Understanding whether the infection is active or chronic can guide treatment decisions and help monitor the effectiveness of therapies.

Biomarkers

HSV 1 + 2 EliSpot

Specification

Specimen Type:

3 x CPDA tube

Vitality of T-cells for LTT: Up to 3 days

Phlebotomy Type:

Blood draw at home or in a clinical setting

Description:

This test reflects the current activity of Human Herpesvirus 7 (HHV-7) in chronic and recent infections.

HHV-7 is a member of the herpesvirus family, closely related to HHV-6. It is commonly found in the general population and typically infects children, often without causing any symptoms. However, it can be associated with various clinical conditions, particularly in immunocompromised individuals.

The EliSpot is highly sensitive and can detect even one single HHV-7-reactive T-cell. With detection levels that can be as low as one cell in 100,000, the EliSpot is one of the most sensitive cellular assays available.

Methodology:
HHV-7 EliSpot (T-Cell-Spot / IGRA: Interferon-Gamma-Release Assay)

When should I use:
When a recent or chronic case of HHV-7 infection is suspected.

Other details:
AONM has checklists that help identify the most likely viral or bacterial infections to test for, based on patient symptoms. Please see  https://aonm.org/checklists-for-testing/ or contact AONM at 03331 210305 or email info@aonm.org. We also offer different viral and bacterial panels and are always happy to advise on testing options. The EliSpot can be helpful when monitoring therapies.

The EliSpot should usually become negative about 4 to 8 weeks after the completion of an effective therapy.

Human Herpesvirus 7 (HHV-7):

• Symptoms:

Fever: Sudden high fever, often without other symptoms.

Rash: A rash may appear following the fever, similar to roseola caused by HHV-6.

Fatigue: Persistent tiredness and weakness.

Swollen Lymph Nodes: Particularly in the neck.

Respiratory Symptoms: Mild respiratory symptoms such as a cough or runny nose.

Irritability: Common in young children during the acute phase of infection.

Other Symptoms: HHV-7 has been linked to various conditions such as encephalitis, febrile seizures, and reactivation of other herpesviruses, particularly in immunocompromised patients.

Biomarkers

HHV-7 EliSpot

Specification

Specimen Type:

3 x CPDA tube

Vitality of T-cells for LTT: Up to 3 days

Phlebotomy Type:

Blood draw at home or in a clinical setting