Lipid peroxides in blood serum.
– Lipid peroxides is an oxidative stress marker.
– Lipid peroxides indicate damage to cell membranes from oxidation.
– Lipid peroxidation is a free radical-mediated chain of reactions that, once initiated, results in an oxidative deterioration of polyunsaturated lipids.
Lipid peroxides are oxidative degradation products of lipids, generated by a free radical chain reaction. Because of their abundance of reactive hydrogens, polyunsaturated fatty acids are highly susceptible to lipid peroxidation, which compromises the integrity and function of the cell membrane in which they reside.
Lipid Peroxides are a direct indicator of oxidative damage to polyunsaturated fatty acids (PUFAs), suggesting that production of reactive oxygen species (=ROS) has been inadequately balanced by antioxidants, esp. fat-soluble. Lipid peroxidation in cell membranes results in cellular dysfunction and is increased in many disease states. Lipid Peroxides are also increased in tissues that are poisoned by toxins.
Concentrations of lipid peroxides may be measured in urine or serum, but serum has superior sensitivity to slight increases in lipid peroxidation. It has gained general acceptance in research and clinical laboratory as a standard means of assessing the body’s antioxidant capability and overall oxidative stress.
Whenever total antioxidant capacity is inadequate to meet the oxidative challenge, cell membrane oxidation increases, releasing lipid peroxides.
- Specimen Type:
- Venous blood
- Phlebotomy Type:
- IN-CLINIC
- SKU:
- 51