Oxidative Stress

The Genova Diagnostics Oxidative Stress 2.0 test is a urine test designed to evaluate oxidative stress levels and the body's antioxidant capacity. This test provides valuable insights into the balance between free radicals and antioxidants, which is crucial for understanding cellular health, aging, and the risk of chronic diseases.

Key Components of the Genova Oxidative Stress 2.0 Test

1. Oxidative Stress Markers:

   • 8-OHdG (8-hydroxy-2'-deoxyguanosine): A marker of oxidative damage to DNA, elevated levels indicate increased oxidative stress.
   • F2-isoprostanes: Products of lipid peroxidation, which indicate oxidative damage to cell membranes.

2. Antioxidant Capacity:

   • Glutathione: Measures levels of this critical antioxidant that protects cells from oxidative damage.
   • Vitamin C (Ascorbic Acid): Assesses the level of this vital antioxidant that neutralizes free radicals.
   • Coenzyme Q10: An essential component in the electron transport chain and an important antioxidant.

3. Additional Markers:

   • Superoxide Dismutase (SOD): Enzyme that protects against superoxide radicals.
   • Catalase: Enzyme that helps decompose hydrogen peroxide, a reactive oxygen species.

Benefits of the Oxidative Stress 2.0 Test

1. Comprehensive Assessment: Provides a detailed analysis of oxidative stress and antioxidant defenses, offering a complete picture of oxidative balance.
2. Identifying Imbalances: Helps identify oxidative stress levels and antioxidant deficiencies that can contribute to various health issues, including chronic diseases, aging, and inflammatory conditions.
3. Guiding Interventions: Provides valuable information for healthcare providers to develop personalized interventions aimed at reducing oxidative stress and enhancing antioxidant capacity.
4. Monitoring Progress: Useful for tracking the effectiveness of antioxidant therapy and lifestyle changes designed to reduce oxidative stress.