Varicella Zoster Virus (VZV) Elispot

Varicella Zoster Virus (VZV) EliSpot
AONM/ArminLabs

"AONM have checklists that help identify the most likely viral or bacterial infections to test for, based on patient symptoms. Please see https://aonm.org/checklists-for-testing/ or contact AONM at 03331 210305 or email info@aonm.org. We also offer different viral and bacterial panels, and are always happy to advise on testing options."

Please note this test requires a blood draw, please organise a phlebotomist for your patient. A return courier fee of £50 is included in this test price

Description:
This test reflects the current activity of Varicella Zoster Virus (VZV), the virus responsible for both chickenpox (varicella) and shingles (herpes zoster), in chronic and recent infections.

The EliSpot is highly sensitive and can detect even one single VZV-reactive T-cell. With detection levels that can be as low as one cell in 100,000, the EliSpot is one of the most sensitive cellular assays available.

Methodology:
VZV Elispot (T-Cell-Spot / IGRA: Interferon-Gamma-Release Assay)

When should I use:
When a recent or chronic case of VZV infection is suspected.

Other details:
AONM has checklists that help identify the most likely viral or bacterial infections to test for, based on patient symptoms. Please see https://aonm.org/checklists-for-testing/ or contact AONM at 03331 210305 or email info@aonm.org. We also offer different viral and bacterial panels and are always happy to advise on testing options. The EliSpot can be helpful when monitoring therapies.

The EliSpot should usually become negative about 4 to 8 weeks after the completion of an effective therapy.

Varicella Zoster Virus (VZV):

• Description: VZV is a herpesvirus that causes chickenpox (varicella) as a primary infection and shingles (herpes zoster) upon reactivation.
• Symptoms of Chickenpox (Varicella):
• Rash: Itchy, blister-like rash that typically starts on the face, back, or chest before spreading to the rest of the body.
• Fever: Moderate to high fever.
• Fatigue and Weakness: Generalised tiredness and malaise.
• Headache: Mild to severe headaches.
• Loss of Appetite: Reduced desire to eat.
• Symptoms of Shingles (Herpes Zoster):
• Painful Rash: A painful, blistering rash that typically appears on one side of the body or face, often in a stripe.
• Pain: Severe pain, burning, or tingling in the area where the rash develops.
• Fever: Low-grade fever.
• Fatigue: Generalised tiredness and weakness.
• Headache: Moderate to severe headaches.

Biomarkers

Varicella Zoster Virus (VZV) EliSpot

Specification

Specimen Type:

3 x CPDA tube

Vitality of T-cells for LTT: Up to 3 days

Phlebotomy Type:

Blood draw at home or in a clinical setting